A small number of women (approximately 1%) suffer from premature ovarian failure in which their ovarian follicle reserve is exhausted before age 40. Recent studies in mice show that the absence of a tumor suppressor gene, PTEN, in oocytes prematurely induces global follicular activation, depleting the follicle reserve in a manner similar to premature ovarian failure.
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Daikoku, T., Dey, S. Two faces of PTEN. Nat Med 14, 1192–1193 (2008). https://doi.org/10.1038/nm1108-1192
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DOI: https://doi.org/10.1038/nm1108-1192
