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From stem cells to germ cells and back again

Nature Medicine volume 14, pages 1188–1190 (2008)Cite this article

Producing germ cells in vitro would open important new avenues for regenerative medicine, and obtaining alternative sources of pluripotent stem cells is desirable. In this regard, Geijsen et al. have shown that it is possible to differentiate stem cells into cells similar to male gametes, whereas Guan et al. reported the ability to turn undifferentiated germ cells into pluripotent stem cells.

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Figure 1: In vitro differentiation of ES cells into gametes and back.

References

  1. Seydoux, G. & Braun, R.E. Cell 127, 891–904 (2006).

    Google Scholar 

  2. Hofmann, M.C., Hess, R.A., Goldberg, E. & Millan, J.L. Proc. Natl. Acad. Sci. USA 91, 5533–5537 (1994).

    Google Scholar 

  3. Feng, L.X. et al. Science 297, 392–395 (2002).

    Google Scholar 

  4. Kierszenbaum, A.L., Abdullah, M., Ueda, H. & Tres, L.L. Adv. Exp. Med. Biol. 219, 535–560 (1987).

    Google Scholar 

  5. Toyooka, Y., Tsunekawa, N., Akasu, R. & Noce, T. Proc. Natl. Acad. Sci. USA 100, 11457–11462 (2003).

    Google Scholar 

  6. Geijsen, N. et al. Nature 427, 148–154 (2004).

    Google Scholar 

  7. Guan, K. et al. Nature 440, 1199–1203 (2006).

    Google Scholar 

  8. Kanatsu-Shinohara, M. et al. Cell 119, 1001–1012 (2004).

    Google Scholar 

  9. Hubner, K. et al. Science 300, 1251–1256 (2003).

    Google Scholar 

  10. Novak, I. et al. Stem Cells 24, 1931–1936 (2006).

    Google Scholar 

  11. Nayernia, K. et al. Dev. Cell 11, 125–132 (2006).

    Google Scholar 

  12. Kanatsu-Shinohara, M. et al. Biol. Reprod. 78, 681–687 (2008).

    Google Scholar 

  13. Clark, A.T. et al. Hum. Mol. Genet. 13, 727–739 (2004).

    Google Scholar 

  14. Conrad, S. et al. Nature published online, doi: 10.1038/nature07404 (8 October 2008).

Download references

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Authors and Affiliations

  1. Marco Conti and Linda Giudice are in the Center for Reproductive Sciences and the Department of Obstetrics and Gynecology and Reproductive Sciences, University of California at San Francisco, 513 Parnassus Avenue, Health Sciences West 1656, Box 0556, San Francisco, California 94143, USA. contim@obgyn.ucsf.edu,

    Marco Conti & Linda Giudice

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  1. Marco Conti
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  2. Linda Giudice
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Conti, M., Giudice, L. From stem cells to germ cells and back again. Nat Med 14, 1188–1190 (2008). https://doi.org/10.1038/nm1108-1188

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