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Worms tame mast cells

A protein produced by parasitic roundworms that inhibits the inflammatory response is shown to prevent mast cell activation. The protein could potentially be used for the management of allergies and asthma (pages 1375–1381).

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Figure 1: ES-62, a secreted phosphorylcholine-containing glycoprotein from a parasitic helminth, inhibits FcɛRI-initiated mast cell activation.

Kim Caesar


  1. Harnett, W. & Harnett, M.M. Clin. Exp. Pharmacol. Physiol. 33, 511–518 (2006).

    Article  CAS  Google Scholar 

  2. Voehringer, D., Shinkai, K. & Locksley, R.M. Immunity 20, 267–277 (2004).

    Article  CAS  Google Scholar 

  3. Smits, H.H. & Yazdanbakhsh, M. Ann. Med. 39, 428–439 (2007).

    Article  CAS  Google Scholar 

  4. Zaccone, P., Fehervari, Z., Phillips, J.M., Dunne, D.W. & Cooke, A. Parasite Immunol. 28, 515–523 (2006).

    Article  CAS  Google Scholar 

  5. Melendez, A.J. et al. Nat. Med. 13, 1367–1373 (2007).

    Article  Google Scholar 

  6. Galli, S.J. et al. Annu. Rev. Immunol. 23, 749–786 (2005).

    Article  CAS  Google Scholar 

  7. Harnett, W., Goodridge, H.S. & Harnett, M.M. Parasitology 130 Suppl, S63–S68 (2005).

    Article  CAS  Google Scholar 

  8. Gilfillan, A.M. & Tkaczyk, C. Nat. Rev. Immunol. 6, 218–230 (2006).

    Article  CAS  Google Scholar 

  9. Melendez, A.J. & Khaw, A.K. J. Biol. Chem. 277, 17255–17262 (2002).

    Article  CAS  Google Scholar 

  10. Leontieva, O.V. & Black, J.D. J. Biol. Chem. 279, 5788–5801 (2004).

    Article  CAS  Google Scholar 

  11. Hoffmann, K.F., Cheever, A.W. & Wynn, T.A. J. Immunol. 164, 6406–6416 (2000).

    Article  CAS  Google Scholar 

  12. Taylor, M.D. et al. J. Immunol. 174, 4924–4933 (2005).

    Article  CAS  Google Scholar 

  13. Pfarr, K., Heider, U. & Hoerauf, A. Int. J. Parasitol. 36, 661–669 (2006).

    Article  CAS  Google Scholar 

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Pearce, E. Worms tame mast cells. Nat Med 13, 1288–1289 (2007).

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