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APC and colon cancer: two hits for one

Two studies suggest how mutations in the APC tumor suppressor gene can contribute to chromosomal aberrations in precancerous cells.

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Figure 1: APC-mediated tetraploidy.

Kim Caesar

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Ceol, C., Pellman, D. & Zon, L. APC and colon cancer: two hits for one. Nat Med 13, 1286–1287 (2007). https://doi.org/10.1038/nm1107-1286

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