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Blocking HDACs boosts regulatory T cells

Histone deacetylase inhibitors, which are in clinical use as anticancer agents, also affect the biology of regulatory T cells. These inhibitors may also hold promise as immunomodulatory drugs (pages 1299–1307).

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Figure 1: Histone deacetylase inhibitors (HDACi) promote Treg cell fate in vivo.

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Reddy, P., Zou, W. Blocking HDACs boosts regulatory T cells. Nat Med 13, 1282–1284 (2007). https://doi.org/10.1038/nm1107-1282

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