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Alzheimer's APP mangles mitochondria

New findings in humans examine how mitochondrial function declines during Alzheimer disease.

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Figure 1: Mitochondria and Alzheimer disease.

Ann Thomson

References

  1. Gouras, G.K. et al. Am. J. Pathol. 156, 15–20 (2000).

    Article  CAS  Google Scholar 

  2. Oddo, S. et al. Neuron 39, 409–421 (2003).

    Article  CAS  Google Scholar 

  3. Almeida, C.G., Takahashi, R.H. & Gouras, G.K. J. Neurosci. 26, 4277–4288 (2006).

    Article  CAS  Google Scholar 

  4. Devi, L., Prabhu, B.M., Galati, D.F., Avadhani, N.G. & Anandatheerthavarada, H.K. J. Neurosci. 26, 9057–9068 (2006).

    Article  CAS  Google Scholar 

  5. Anandatheerthavarada, H.K., Biswas, G., Robin, M.A. & Avadhani, N.G. J. Cell Biol. 161, 41–54 (2003).

    Article  CAS  Google Scholar 

  6. Parker, W.D. Jr., Parks, J., Filley, C.M. & Kleinschmidt-DeMasters, B.K. Neurology 44, 1090–1096 (1994).

    Article  Google Scholar 

  7. Hirai, K. et al. J. Neurosci. 21, 3017–3023 (2001).

    Article  CAS  Google Scholar 

  8. Casley, C.S., Canevari, L., Land, J.M., Clark, J.B. & Sharpe, M.A. J. Neurochem. 80, 91–100 (2002).

    Article  CAS  Google Scholar 

  9. Lustbader, J.W. et al. Science 304, 448–452 (2004).

    Article  CAS  Google Scholar 

  10. Crouch, P.J. et al. J. Neurosci. 25, 672–679 (2005).

    Article  CAS  Google Scholar 

  11. Manczak, M. et al. Hum. Mol. Genet. 15, 1437–1449 (2006).

    Article  CAS  Google Scholar 

  12. Hansson, C.A. et al. J. Biol. Chem. 279, 51654–51660 (2004).

    Article  CAS  Google Scholar 

  13. Leissring, M.A. et al. Biochem. J. 383, 439–446 (2004).

    Article  CAS  Google Scholar 

  14. Falkevall, A. et al. J. Biol. Chem. 281, 29096–29104 (2006).

    Article  CAS  Google Scholar 

  15. Robin, M.A. et al. J. Biol. Chem. 277, 40583–40593 (2002).

    Article  CAS  Google Scholar 

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Lin, M., Beal, M. Alzheimer's APP mangles mitochondria. Nat Med 12, 1241–1243 (2006). https://doi.org/10.1038/nm1106-1241

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