TLRs play good cop, bad cop in the lung

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Toll-like receptors act as mediators of injury or repair in the inflamed lung, and the balance depends on the integrity of a component of the extracellular matrix (pages 1173–1179).

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Figure 1: Jiang et al. found that TLR2 and TLR4 act as key sensors of the extracellular matrix component hyaluronan in the lung.

Katie Ris

References

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    Jiang, D. et al. Nat. Med. 11, 1173–1179 (2005).

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    O'Neill, L.A.J. Sci. Am. 292, 24–31 (2005).

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    Taylor, K.R. et al. J. Biol. Chem. 279, 17079–17084 (2004).

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    Rakoff-Nahoum, S. et al. Cell 118, 229–241 (2004).

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O'Neill, L. TLRs play good cop, bad cop in the lung. Nat Med 11, 1161–1162 (2005) doi:10.1038/nm1105-1161

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