Cancer: the matrix is now in control

Article metrics

The extracellular matrix is traditionally regarded as a facilitator of tumor progression, providing an environment in which cells can grow and metastasize. Three new studies take the matrix out of this context and suggest that the microenvironment can not only subsidize, but also initiate, the oncogenic conversion of epithelial cells.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The tumor microenvironment can drive the onset of cancer.

Katie Ris

References

  1. 1

    Giancotti, F.G. & Tarone, G. Annu. Rev. Cell. Dev. Biol. 19, 173–206 (2003).

  2. 2

    Hanahan, D. & Weinberg, R.A. Cell 100, 57–70 (2000).

  3. 3

    Radisky, D.C. et al. Nature 436, 123–127 (2005).

  4. 4

    List, K. et al. Genes Dev. 19, 1934–1950 (2005).

  5. 5

    Paszek, M.J. et al. Cancer Cell 8, 241–254 (2005).

  6. 6

    Overall, C.M. & López-Otín, C. Nat. Rev.Cancer 2, 657–672 (2002).

  7. 7

    Egeblad, M. & Werb, Z. Nat. Rev. Cancer 2, 163–176 (2002).

  8. 8

    Sternlicht, M.D. et al. Cell 98, 137–146 (1999).

  9. 9

    Benaud, C.M, Oberst, M., Dickson, R.B. & Lin, C.Y. Clin. Exp. Metastasis 19, 639–649 (2002).

  10. 10

    Lee, S.L., Dickson, R.B. & Lin, C.Y. J. Biol. Chem. 275, 36720–36725 (2000).

  11. 11

    Trusolino, L. & Comoglio, P.M. Nat. Rev. Cancer 2, 289–300 (2002).

  12. 12

    Noonan, F.P, Otsuka, T., Bang, S., Anver, M.R. & Merlino, G. Cancer Res. 60, 3738–3743 (2000).

  13. 13

    O'Brien, L.E., Zegers, M.M. & Mostov, K.E. Nat. Rev. Mol. Cell. Biol. 3, 531–537 (2002).

  14. 14

    Coussens, L.M. & Werb, Z. Nature 420, 860–867 (2002).

  15. 15

    Boccaccio, C. et al. Nature 434, 396–400 (2005).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Comoglio, P., Trusolino, L. Cancer: the matrix is now in control. Nat Med 11, 1156–1158 (2005) doi:10.1038/nm1105-1156

Download citation

Further reading