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Muscles flex, axons die

Molecules that regulate contraction in skeletal muscle have now found a place in the axon. In response to injury, the ryanodine receptor mediates the release of internal calcium stores, which contributes to axonal damage.

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Figure 1: Mechanisms of axonal injury.
Figure 2: Channel meets receptor.

Reprinted with permission from Elsevier Science

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Wrathall, J. Muscles flex, axons die. Nat Med 9, 1347–1348 (2003). https://doi.org/10.1038/nm1103-1347

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