Pharmacological prevention of Parkinson disease in Drosophila

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Figure 1: Geldanamycin treatment prevents dopaminergic cell loss in α-synuclein transgenic flies.


  1. 1

    Polymeropoulos, M.H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045–2047 (1997).

    CAS  Article  Google Scholar 

  2. 2

    Kruger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet. 18, 106–108 (1998).

    CAS  Article  Google Scholar 

  3. 3

    Spillantini, M.G. et al. α-Synuclein in Lewy bodies. Nature 388, 839–840 (1997).

    CAS  Article  Google Scholar 

  4. 4

    Feany, M.B. & Bender, W.W. A Drosophila model of Parkinson's disease. Nature 404, 394–398 (2000).

    CAS  Article  Google Scholar 

  5. 5

    Auluck, P.K., Chan, H.Y., Trojanowski, J.Q., Lee, V.M.-Y. & Bonini, N.M. Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295, 865–868 (2002).

    CAS  Article  Google Scholar 

  6. 6

    Whitesell, L., Mimnaugh, E.G., De Costa, B., Myers, C.E. & Neckers, L.M. Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proc. Natl. Acad. Sci. USA 91, 8324–8328 (1994).

    CAS  Article  Google Scholar 

  7. 7

    Zou, J., Guo, Y., Guettouche, T., Smith, D.F. & Voellmy, R. Repression of heat shock transcription factor HSF1 activation by Hsp90 (Hsp90 complex) that forms a stress-sensitive complex with HSF1. Cell 94, 471–480 (1998).

    CAS  Article  Google Scholar 

  8. 8

    Sittler, A. et al. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum. Mol. Genet. 10, 1307–1315 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Rutherford, S.L. & Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 396, 336–342 (1998).

    CAS  Article  Google Scholar 

  10. 10

    Lang, A.E. & Lozano, A.M. Parkinson's disease. Second of two parts. N. Engl. J. Med. 339, 1130–1143 (1998).

    CAS  Article  Google Scholar 

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Correspondence to Nancy M. Bonini.

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Auluck, P., Bonini, N. Pharmacological prevention of Parkinson disease in Drosophila. Nat Med 8, 1185–1186 (2002).

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