Pharmacological prevention of Parkinson disease in Drosophila

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Geldanamycin treatment prevents dopaminergic cell loss in α-synuclein transgenic flies.

References

  1. 1

    Polymeropoulos, M.H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045–2047 (1997).

    CAS  Article  Google Scholar 

  2. 2

    Kruger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet. 18, 106–108 (1998).

    CAS  Article  Google Scholar 

  3. 3

    Spillantini, M.G. et al. α-Synuclein in Lewy bodies. Nature 388, 839–840 (1997).

    CAS  Article  Google Scholar 

  4. 4

    Feany, M.B. & Bender, W.W. A Drosophila model of Parkinson's disease. Nature 404, 394–398 (2000).

    CAS  Article  Google Scholar 

  5. 5

    Auluck, P.K., Chan, H.Y., Trojanowski, J.Q., Lee, V.M.-Y. & Bonini, N.M. Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295, 865–868 (2002).

    CAS  Article  Google Scholar 

  6. 6

    Whitesell, L., Mimnaugh, E.G., De Costa, B., Myers, C.E. & Neckers, L.M. Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proc. Natl. Acad. Sci. USA 91, 8324–8328 (1994).

    CAS  Article  Google Scholar 

  7. 7

    Zou, J., Guo, Y., Guettouche, T., Smith, D.F. & Voellmy, R. Repression of heat shock transcription factor HSF1 activation by Hsp90 (Hsp90 complex) that forms a stress-sensitive complex with HSF1. Cell 94, 471–480 (1998).

    CAS  Article  Google Scholar 

  8. 8

    Sittler, A. et al. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum. Mol. Genet. 10, 1307–1315 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Rutherford, S.L. & Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 396, 336–342 (1998).

    CAS  Article  Google Scholar 

  10. 10

    Lang, A.E. & Lozano, A.M. Parkinson's disease. Second of two parts. N. Engl. J. Med. 339, 1130–1143 (1998).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Nancy M. Bonini.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Auluck, P., Bonini, N. Pharmacological prevention of Parkinson disease in Drosophila. Nat Med 8, 1185–1186 (2002). https://doi.org/10.1038/nm1102-1185

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing