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Pharmacological prevention of Parkinson disease in Drosophila

Nature Medicine volume 8, pages 11851186 (2002) | Download Citation

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References

  1. 1.

    et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045–2047 (1997).

  2. 2.

    et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet. 18, 106–108 (1998).

  3. 3.

    et al. α-Synuclein in Lewy bodies. Nature 388, 839–840 (1997).

  4. 4.

    & A Drosophila model of Parkinson's disease. Nature 404, 394–398 (2000).

  5. 5.

    , , , & Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295, 865–868 (2002).

  6. 6.

    , , , & Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proc. Natl. Acad. Sci. USA 91, 8324–8328 (1994).

  7. 7.

    , , , & Repression of heat shock transcription factor HSF1 activation by Hsp90 (Hsp90 complex) that forms a stress-sensitive complex with HSF1. Cell 94, 471–480 (1998).

  8. 8.

    et al. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum. Mol. Genet. 10, 1307–1315 (2001).

  9. 9.

    & Hsp90 as a capacitor for morphological evolution. Nature 396, 336–342 (1998).

  10. 10.

    & Parkinson's disease. Second of two parts. N. Engl. J. Med. 339, 1130–1143 (1998).

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Author information

Affiliations

  1. Department of Neuroscience, University of Pennsylvania and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    • Pavan K. Auluck
    •  & Nancy M. Bonini
  2. Department of Biology and Howard Hughes Medical Institute University of Pennsylvania and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    • Nancy M. Bonini

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The authors declare no competing financial interests.

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Correspondence to Nancy M. Bonini.

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DOI

https://doi.org/10.1038/nm1102-1185

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