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Reply to “Confounding factors complicate conclusions in aly model”

Nature Medicine volume 7, pages 1165–1166 (2001)Cite this article

Lakkis replies

Using Lta−/− and Ltbr−/− mice as models to study the role of secondary lymphoid organs in the alloimmune response, Chin et al. present data that seem to challenge our conclusion that the immune response to a vascularized organ graft can not be initiated in the absence of secondary lymphoid organs4, which is based on a systematic study of allograft rejection in the alymphoplastic (aly/aly) mouse. Although the findings of Chin et al. are intriguing, they do not refute our conclusion. We carefully excluded in our study the possibility that failure to mount an alloimmune response in splenectomized aly/aly mice resulted from an intrinsic abnormality in aly/aly T-lymphocyte activation or homing.

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  1. Yale University School of Medicine Sections of Nephrology and Immunobiology, New Haven, Connecticut, USA

    Fadi G. Lakkis

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Lakkis, F. Reply to “Confounding factors complicate conclusions in aly model”. Nat Med 7, 1165–1166 (2001). https://doi.org/10.1038/nm1101-1165b

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