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The effect of increased salt intake on blood pressure of chimpanzees

Nature Medicine volume 1, pages 1009–1016 (1995)Cite this article

Abstract

A colony of 26 chimpanzees given a fruit and vegetable diet of very low Na and high K intake were maintained in long–standing, socially stable small groups for three years. Half of them had salt added progressively to their diet during 20 months. This addition of salt within the human dietetic range caused a highly significant rise in systolic, mean and diastolic blood pressure. The change reversed completely by six months after cessation of salt. The effect of salt differed between chimpanzees, some having a large blood pressure rise and others small or no rise. These results in the species phylogenetically closest to humans bear directly on causation of human hypertension, particularly in relation to migration of preliterate people, with low Na diet, to a Western urban lifestyle with increased salt intake. The hedonic liking for salt and avid ingestion was apt during human prehistory involving hunter–gatherer–scavenger existence in the interior of continents with a scarcity of salt, but is maladaptive in urban technological life with salt cheap and freely available.

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References

  1. MacGregor, G. Sodium is more important than calcium in essential hypertension. Hypertension 7, 628–640 (1985).

    Article  CAS  Google Scholar 

  2. Dahl, L.K. Salt and hypertension. Am. J. Clin. Nutr. 25, 231–244 (1972).

    Article  CAS  Google Scholar 

  3. Simpson, F.O. Salt and hypertension: A skeptical review of the evidence. Clin. Sci. 57, 463S–480S (1979).

    Article  Google Scholar 

  4. Altschul, A.M. & Groment, J.K. Sodium intake and sodium sensitivity. Nutr. Rev. 38, 393–402 (1980).

    Article  CAS  Google Scholar 

  5. Freis, E.D., Salt, volume and the prevention of hypertension. Circulation 53, 589–595 (1976).

    Article  CAS  Google Scholar 

  6. Swales, J. Dietary salt and hypertension. Lancet i, 1117–1179 (1980).

    Google Scholar 

  7. Swales, J.D. Salt saga continued. Salt has only small importance in hypertension [Editorial]. Br. Med. J. 297, 307–308 (1988).

    Article  CAS  Google Scholar 

  8. Rose, G. & Stamler, J. The INTERSALT study: Background, methods and main results. J. hum. Hypertens. 3, 283–288 (1989).

    CAS  PubMed  Google Scholar 

  9. McCarron, D.A., Morris, C.D., Henry, H.J. & Stanton, J.L. Blood pressure and nutrient intake in the United States. Science 224, 1392–1398 (1994).

    Article  Google Scholar 

  10. Hanneman, R.L. The politics of sodium restriction in the United States. 7th Symposium on Salt II, 231–239 (Elsevier Science, Amsterdam, 1993).

    Google Scholar 

  11. Brown, J.J. et al. Salt and hypertension. Lancet ii, 456 (1984)

    Article  Google Scholar 

  12. Denton, D. The Hunger for Salt: An Anthropological, Physiological and Medical Analysis (Springer, Berlin, 1982).

    Google Scholar 

  13. Denton, D. Hypertension: A malady of civilization? in Systemic Effects of Antihypertensive Agents (ed. Sambhi, M.P.) 577–583 (Symposia Specialists, New York, 1976).

    Google Scholar 

  14. Gliebermann, L. Blood pressure and dietary salt in human populations. Ecol. Food Nutr. 2, 143–156 (1973).

    Article  Google Scholar 

  15. Trowell, H.C. From normotension to hypertension in Kenyans and Ugandans. East Africa Med. J.. 57, 167–173 (1980).

    CAS  Google Scholar 

  16. Laragh, J.H. & Pecker, M.S. Dietary sodium and essential hypertension: Some myths, hopes and truths. Ann. intern. Med. 98, 735–743 (1983).

    Article  CAS  Google Scholar 

  17. Poulter, N.R. & Sever, P.S. Low blood pressure populations and the impact of rural-urban migration. in Textbook of Hypertension (ed. Swales, J.) 22–36 (Blackwell Scientific, Oxford, 1994).

    Google Scholar 

  18. Poulter, N.R., Khaw, K.T., Mugambi, M., Peart, W.S. & Sever, P.S. Migration-induced changes in blood pressure: A controlled longitudinal study. Clin. exp. Pharm. Physiol. 12, 211–216 (1985).

    Article  CAS  Google Scholar 

  19. Poulter, N.R. et al. The Kenyan Luo migration study: Observations on the initiation of a rise in blood pressure. Br. Med. J. 300, 967–972 (1990).

    Article  CAS  Google Scholar 

  20. Pickering, G.W. Salt intake and essential hypertension. Cardiovasc. Rev. Rep. 1, 1–7 (1980).

    Google Scholar 

  21. Page, L.B., Damon, A. & Moellering, R.C. Jr., Antecedents of cardiovascular disease in six Solomon Islands society. Circulation 49, 1132–1146 (1974).

    Article  CAS  Google Scholar 

  22. Truswell, A.S., Kennelly, B.M., Hansen, J.D.L. & Lee, R.B. Blood pressure of !Kung bushmen in Northern Botswana. Am. Heart. J. 84, 5–12 (1972).

    Article  CAS  Google Scholar 

  23. Sinnett, P.F. & Whyte, H.M. Epidemiological studies in a total highland population, Tukisenta, New Guinea. Cardiovascular disease and relevant clinical, electrocardiographic, radiological and biochemical findings. J. chron. Dis. 26, 265–290 (1973).

    Article  CAS  Google Scholar 

  24. Oliver, W.J., Cohen, E.L. & Neel, J.B. Blood pressure, sodium intake and sodium related hormones in the Yanamamo: A ‘no salt’ culture. Circulation 52, 146–151 (1975).

    Article  CAS  Google Scholar 

  25. Oliver, W.J., Neel, J.V., Giekin, R.J. & Cohen, E.L. Hormonal adaptation to the stresses imposed upon sodium balance by pregnancy and lactation in the Yanamamo Indians, a culture without salt. Circulation 63, 110–116 (1981).

    Article  CAS  Google Scholar 

  26. Takahashi, B. An epidemiological approach to the relation between diet and cardiovascular lesions and arteriosclerotic heart disease. Tohoku J. ext. Med. 77, 239–250 (1962).

    Article  CAS  Google Scholar 

  27. Sasaki, N. High blood pressure and the salt intake of the Japanese. Jpn. Heart J. 3, 313–324 (1962).

    Article  CAS  Google Scholar 

  28. Maddocks, I. Blood pressure in Melanesians. Med. J. Australia 20, 1123–1125 (1967).

    Google Scholar 

  29. Eichberg, J.W. & Shade, R.E. “Normal” blood pressure in chimpanzees. J. Med. Primatol. 16, 317–321 (1987).

    CAS  PubMed  Google Scholar 

  30. Rose, B.D. Pathophysiology of Renal Disease 4 (McGraw-Hill, New York, 1981).

    Google Scholar 

  31. Yamori, Y. Hypertensive cardiovascular diseases: Importance of nutrition in pathogenesis and prevention. in Third International Conference on Nutrition in Cardiovascular Diseases. Ann. N.Y. Acad. Sci. 676, 92–104 (1993).

    Google Scholar 

  32. Kawasaki, T., Delea, C.S., Bartter, F.C. & Smith, H. The effect of high sodium and low sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am. J. Med. 64, 193–196 (1978).

    Article  CAS  Google Scholar 

  33. Shimkets, R.A. et al. Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 19, 407–414 (1994).

    Article  Google Scholar 

  34. Leckie, B. & Norman, R. A direct link to salt. Curr. Biol. 5, 260–261 (1995).

    Article  CAS  Google Scholar 

  35. Changnon, N. Yanamamo: The Fierce People (Holt, Rinehart and Winston, New York, 1977).

    Google Scholar 

  36. Kaplan, N.M. Clinical Hypertension (4th edn) 70 (Williams and Wilkins, Baltimore, 1984).

    Google Scholar 

  37. Folkow, B. Salt and hypertension. News Physiol. Sci. 5, 220–224 (1990).

    Google Scholar 

  38. WoldeGabriel, G. et al. Ecological and temporal placement of early Pliocene ho-minids at Aramis, Ethiopia. Nature 371, 330–333 (1994).

    Article  CAS  Google Scholar 

  39. Coppens, Y. East side story: The origin of human kind. Sci. Am. 270, 88–95 (1994).

    Article  CAS  Google Scholar 

  40. The First Humans. The American Museum of Natural History, vol. 1. 46, 54, 65 (Harper Collins, San Francisco, 1993).

  41. Clark, J.D. The Prehistory of Africa (Praeger, New York, 1970).

    Google Scholar 

  42. Issac, G. The diet of early man. World Archeol. (Feb), 278 (1971).

  43. Buss, D.H. Mammary glands and lactation. in Comparative Reproduction of Nonhuman Primates (ed. Hafez, E.S.E.) 315–333 (Thomas, Springfield, Illinois, 1971).

    Google Scholar 

  44. O'Dea, K. Diabetes in Australian aborigines: Impact of the Western diet and lifestyle. J. intern. Med. 232, 103–117 (1992).

    Article  CAS  Google Scholar 

  45. O'Dea, K. Traditional diet and food preferences of Australian aboriginal hunter-gatherers. Phil. Trans. R. Soc. London B334, 233–241 (1991).

    Google Scholar 

  46. O'Dea, K. Obesity and diabetes in “the land of milk and honey”. Diabetes/Metabol. Rev. 8, 373–388 (1992).

    Article  CAS  Google Scholar 

  47. Eaton, S.B. & Konner, M. Paleolithic nutrition: A consideration of its nature and current implications. New Engl. J. Med. 312, 283–289 (1985).

    Article  CAS  Google Scholar 

  48. Stamler, J. Dietary salt and blood pressure. in Third International Conference on Nutrition in Cardiovascular Diseases (eds Lee, K.T., Oike, Y. & Kanazawa, T.) Ann. N.Y. Acad. Sci. 676, 122–156 (1993).

    Google Scholar 

  49. Stamler, J. Blood pressure and high blood pressure: Aspects of risk. Hypertension 18, 95–107 (1991).

    Article  Google Scholar 

  50. Hofman, A., Hazebroek, A. & Valkenburg, H. A randomized trial of sodium intake and blood pressure in newborn infants. JAMA 250, 370–373 (1983).

    Article  CAS  Google Scholar 

  51. Goobbee, D.E. Sodium and potassium. in Textbook of Hypertension (ed. Swales, J.D.) 539–551 (Blackwell, Oxford, 1994).

    Google Scholar 

  52. Nutrient Requirements of Laboratory Animals, No. 10, Nutrient Requirements of the Monkey (Subcommittee on Laboratory Animal Nutrition 29–45, (Natn. Academy of Sciences, Washington, DC, 1972).

  53. Paul, A. & Southgate, D., The Composition of Foods (eds McCance, R.A. & Widdowson, E.) (HM Stationery Office, London, 1978).

    Google Scholar 

  54. Menard, J. & Catt, K.S. Measurement of renin activity, concentrations and substrate in rat plasma and radioimmunoassay of angiotensin I. Endocrinology 90, 422–430 (1972).

    Article  CAS  Google Scholar 

  55. Cushman, D.W. & Cheung, H.S. Spectrophotometric assay and properties of the angiotension-converting enzyme of rabbit lung. Biochem. Pharmacol. 20, 1637–1648 (1971).

    Article  CAS  Google Scholar 

  56. Bradford, M.M. A rapid and sensitive method for the quantitation of micro-gram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248–254 (1976).

    Article  CAS  Google Scholar 

  57. Huu, P., Trung, M.T. & Corvol, P. A direct determination of plasma aldosterone using a specific aldosterone antibody. Steroids 24, 587–598 (1974).

    Article  Google Scholar 

  58. Doucet, C., Huby, T., Chapman, J. & Thillet, J. Lipoprotein(a) in the chimpanzee: relationship of Apo(a) phenotype to elevated plasma Lp(a) levels. J. Lipid Res. 35, 263–270 (1994).

    CAS  PubMed  Google Scholar 

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Author information

Author notes

  1. Nicholas I. Mundy

    Present address: Department of Biology, University of California, Lajolla, California, 92093, USA

  2. Alan Dixson

    Present address: Sub-Department of Animal Behaviour, Madingley, Cambridge University, Cambridge, UK

  3. Pierre Moisson & Anne Marie Pingard

    Present address: Institut Pasteur De Lyon, Unité de Parasitologie Experimentale, Domaine du Poirier, 69210, Lentilly, France

Authors and Affiliations

  1. Howard Florey Institute of Experimental Physiology & Medicine, University of Melbourne, Parkville, 3052, Victoria, Australia

    Derek Denton & Richard Weisinger

  2. Centre International de Recherches Médicates de Franceville, BP 769, Franceville, Gabon

    Nicholas I. Mundy, E. Jean Wickings, Alan Dixson, Pierre Moisson & Anne Marie Pingard

  3. Southwest Foundation for Biomedical Research, W Loop 14, Military Drive, San Antonio, Texas, 78284, USA

    Robert Shade & D. Carey

  4. INSERM Unité 64, Hôpital Tenon, 75970, Paris Cedex, 20, France

    Raymond Ardaillou & Françhise Paillard

  5. INSERM, Unité 321, Hôpital de la Pitié, Pavillion Benjamin Delessert, 83 boulevard de l'Hôpital, 75651, Paris Cedex, 13, France

    John Chapman & Joelle Thillet

  6. INSERM, Physiologie et Pathologie Expérimentale Vasculaires, Unité 367,17rue du Fer à Moulin, 75005, Paris, France

    Jean Baptiste Michel

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Denton, D., Weisinger, R., Mundy, N. et al. The effect of increased salt intake on blood pressure of chimpanzees. Nat Med 1, 1009–1016 (1995). https://doi.org/10.1038/nm1095-1009

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