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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

Abstract

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

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Figure 1: βT-Eif4e mice develop tumors of various histological origins.
Figure 2: eIF-4E cooperates with c-Myc in B-cell lymphomagenesis.

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Acknowledgements

This work was partially supported by the National Cancer Institute and the Irma T. Hirschl/Monique Weill-Caulier Award to P.P.P. We thank L. DiSantis for editing the manuscript and M. Barna, L. Longo and C. Tonini for support and suggestions.

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Correspondence to Pier Paolo Pandolfi.

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Ruggero, D., Montanaro, L., Ma, L. et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 10, 484–486 (2004). https://doi.org/10.1038/nm1042

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