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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

Nature Medicine volume 10, pages 484–486 (2004)Cite this article

Abstract

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

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Figure 1: βT-Eif4e mice develop tumors of various histological origins.
Figure 2: eIF-4E cooperates with c-Myc in B-cell lymphomagenesis.

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Acknowledgements

This work was partially supported by the National Cancer Institute and the Irma T. Hirschl/Monique Weill-Caulier Award to P.P.P. We thank L. DiSantis for editing the manuscript and M. Barna, L. Longo and C. Tonini for support and suggestions.

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Author notes

  1. Davide Ruggero

    Present address: Fox Chase Cancer Center, Human Genetics Program, 333 Cottman Avenue, Philadelphia, Pennsylvania, 19111, USA

Authors and Affiliations

  1. Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA

    Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu & Pier Paolo Pandolfi

  2. Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA

    Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Carlos Cordon-Cardo & Pier Paolo Pandolfi

  3. Università di Bari–Dipartimento di Biochimica Medica e Biologica Medica, Piazzale Giulio Cesare, Bari, 70124, Italy

    Paola Londei

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  1. Davide Ruggero
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Correspondence to Pier Paolo Pandolfi.

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Ruggero, D., Montanaro, L., Ma, L. et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 10, 484–486 (2004). https://doi.org/10.1038/nm1042

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