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A small kiss of death for cancer

The tumor suppressor p53 is inactivated by genetic mutations in many cancers, except for neuroblastoma. New findings show that this cancer reversibly inhibits p53 through a microRNA, miR-380-5p (pages 1134–1140). Blocking it to restore p53 function may be an attractive therapeutic option for neuroblastomas.

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Figure 1: A miRNA-380-5p regulates tumor transformation through p53.

Marina Corral

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Correspondence to Angelika Eggert.

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Eggert, A., Schulte, J. A small kiss of death for cancer. Nat Med 16, 1079–1081 (2010). https://doi.org/10.1038/nm1010-1079

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