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High glucose, no cry

Just as a Bob Marley tune can elicit a visceral pull, a rhythmic awakening can shake up metabolism, with a new study in mice showing that cryptochrome (CRY) in the liver controls glucose levels during fasting and improves insulin sensitivity—introducing a new possible therapy for type II diabetes (pages 1152–1156).

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Figure 1: Circadian regulators of glucose in the liver.

Marina Corral

References

  1. Tu, B.P. & McKnight, S.L. Nat. Rev. Mol. Cell Biol. 7, 696–701 (2006).

    Article  CAS  Google Scholar 

  2. Green, C.B., Takahashi, J.S. & Bass, J. Cell 134, 728–742 (2008).

    Article  CAS  Google Scholar 

  3. Welsh, D.K., Takahashi, J.S. & Kay, S.A. Annu. Rev. Physiol. 72, 551–577 (2010).

    Article  CAS  Google Scholar 

  4. Balsalobre, A., Damiola, F. & Schibler, U. Cell 93, 929–937 (1998).

    Article  CAS  Google Scholar 

  5. Zhang, E.E. et al. Nat. Med. 16, 1152–1156 (2010).

    Article  CAS  Google Scholar 

  6. Baggs, J.E. et al. PLoS Biol. 7, e52 (2009).

    Article  Google Scholar 

  7. O'Neill, J.S., Maywood, E.S., Chesham, J.E., Takahashi, J.S. & Hastings, M.H. Science 320, 949–953 (2008).

    Article  CAS  Google Scholar 

  8. Dupuis, J. et al. Nat. Genet. 42, 105–116 (2010).

    Article  CAS  Google Scholar 

  9. Yoon, J.C. et al. Nature 413, 131–138 (2001).

    Article  CAS  Google Scholar 

  10. Rodgers, J.T. et al. Nature 434, 113–118 (2005).

    Article  CAS  Google Scholar 

  11. Lamia, K.A., Storch, K.F. & Weitz, C.J. Proc. Natl. Acad. Sci. USA 105, 15172–15177 (2008).

    Article  CAS  Google Scholar 

  12. Turek, F.W. et al. Science 308, 1043–1045 (2005).

    Article  CAS  Google Scholar 

  13. Marcheva, B. et al. Nature 466, 627–631 (2010).

    Article  CAS  Google Scholar 

  14. Rudic, R.D. et al. PLoS Biol. 2, e377 (2004).

    Article  Google Scholar 

Download references

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Correspondence to Joseph Bass.

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Competing interests

J.B. is a member of the scientific advisory board of Reset Therapeutics. He also receives support from Amylin Pharmaceuticals.

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Bass, J. High glucose, no cry. Nat Med 16, 1074–1076 (2010). https://doi.org/10.1038/nm1010-1074

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