Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Between Bedside and Bench
  • Published:

Bleeding in the brain: Amyloid-β may keep clots away

Nature Medicine volume 15, pages 1132–1133 (2009)Cite this article

Bedside to Bench

Findings within the past few years have hinted that a domain that inhibits proteases, called a Kunitz protease inhibitor (or KPI) domain, found in several isoforms of β-amyloid (Aβ), inactivates proteins in the blood that cause clotting1,2,3,4,5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Amyloid-related cerebral hemorrhages.

Kyra Becker

References

  1. Xu, F., Previti, M.L. & Van Nostrand, W.E. Stroke 38, 2598–2601 (2007).

    Article  CAS  Google Scholar 

  2. Xu, F. et al. J. Neurosci. 29, 5666–5670 (2009).

    Article  CAS  Google Scholar 

  3. Schmaier, A.H. et al. J. Clin. Invest. 92, 2540–2545 (1993).

    Article  CAS  Google Scholar 

  4. Smith, R.P., Higuchi, D.A. & Broze, G.J. Science 248, 1126–1128 (1990).

    Article  CAS  Google Scholar 

  5. Van Nostrand, W.E., Schmaier, A.H., Farrow, J.S. & Cunningham, D.D. Science 248, 745–748 (1990).

    Article  CAS  Google Scholar 

  6. Tagaya, M. et al. J. Cereb. Blood Flow Metab. 21, 835–846 (2001).

    Article  CAS  Google Scholar 

  7. Milner, R. et al. Stroke 39, 191–197 (2008).

    Article  Google Scholar 

  8. Okada, Y., Copeland, B.R., Fitridge, R., Koziol, J.A. & del Zoppo, G.J. Stroke 25, 1847–1853 (1994).

    Article  CAS  Google Scholar 

  9. Ponte, P. et al. Nature 331, 525–527 (1988).

    Article  CAS  Google Scholar 

  10. Broze, G.J. Jr., Girard, T.J. & Novotny, W.F. Biochemistry 29, 7539–7546 (1990).

    Article  CAS  Google Scholar 

  11. Corral-Rodriguez, M.A., Macedo-Ribeiro, S., Barbosa Periero, P.J. & Fuentes-Prior, P. Insect Biochem. Mol. Biol. 39, 1–17 (2009).

    Article  Google Scholar 

  12. Van Nostrand, W.E. et al. Nature 241, 546–549 (1989).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gregory J. del Zoppo is Professor of Medicine in Hematology and Adjunct Professor of Neurology at the University of Washington, Harborview Medical Center, Seattle, Washington, USA.,

    Gregory J del Zoppo

Authors
  1. Gregory J del Zoppo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gregory J del Zoppo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

del Zoppo, G. Bleeding in the brain: Amyloid-β may keep clots away. Nat Med 15, 1132–1133 (2009). https://doi.org/10.1038/nm1009-1132

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1009-1132

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing