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Epilepsy: synapses stuck in childhood

Mouse experiments show how mutation of a gene involved in human epilepsy causes hyperexcitability of the neuronal network (pages 1208–1214). The mutations interfere with the maturation of excitatory synapses during postnatal development.

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Figure 1: Effects of LGI1 mutation on circuit development and excitability.

Marina Corral

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Correspondence to Matteo Caleo.

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Caleo, M. Epilepsy: synapses stuck in childhood. Nat Med 15, 1126–1127 (2009). https://doi.org/10.1038/nm1009-1126

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