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Preserving fertility during cancer treatment

Imatinib (trade name Gleevec) preserves fertility in female mice treated with the common chemotherapeutic agent cisplatin. Imatinib seems to block an apoptotic pathway activated by cisplatin in ovarian germ cells (pages 1179–1185). The findings could lead to new ways to protect germ cells from the damaging effects of cancer treatment.

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Figure 1: Imatinib protects primoridal follicles from cisplatin-mediated death.


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Correspondence to Teresa K Woodruff.

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Woodruff, T. Preserving fertility during cancer treatment. Nat Med 15, 1124–1125 (2009).

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