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Gateway to the diseased brain

The blood-brain barrier constitutes a major obstacle to effective treatment of diseases affecting the central nervous system. A new strategy to target specifically the endothelium of diseased brain may allow the development of more effective gene-based therapies (pages 1215–1218).

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Figure 1: Retargeting of AAV vectors to the diseased brain endothelium.

Katie Vicari


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Correspondence to Katherine A High.

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Mingozzi, F., High, K. Gateway to the diseased brain. Nat Med 15, 1123–1124 (2009).

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