The blood-brain barrier constitutes a major obstacle to effective treatment of diseases affecting the central nervous system. A new strategy to target specifically the endothelium of diseased brain may allow the development of more effective gene-based therapies (pages 1215–1218).
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Mingozzi, F., High, K. Gateway to the diseased brain. Nat Med 15, 1123–1124 (2009). https://doi.org/10.1038/nm1009-1123
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DOI: https://doi.org/10.1038/nm1009-1123