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'Multipurpose oxidase' in atherogenesis

Nature Medicine volume 13, pages 1146–1147 (2007)Cite this article

A new mechanism of protein carbamylation links inflammation, cardiovascular disease and smoking (pages 1176–1184).

Despite being much-studied and a worldwide scourge, the pathogenesis of atherosclerotic cardiovascular disease remains incompletely understood. Although inflammation and oxidative stress are generally believed to have important roles in this disease1, the molecular mechanisms by which they promote the formation of plaques within the cardiovascular wall (atherosclerosis) are still unclear. In this issue of Nature Medicine, Wang et al.2 reveal a previously undescribed biochemical pathway that involves the enzyme myeloperoxidase (MPO) and that leads to protein carbamylation, suggesting a new predictive test and therapeutic target of cardiovascular disease.

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Figure 1: Protein carbamylation by MPO in atherosclerosis.

Kim Caesar

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Authors and Affiliations

  1. Daniel J. Rader is in the Institute for Translational Medicine and Therapeutics, the Cardiovascular Institute and the Institute for Diabetes Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. rader@mail.med.upenn.edu,

    Daniel J Rader

  2. Harry Ischiropoulos is in the Stokes Research Institute and the Departments of Pediatrics and Pharmacology, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. ischirop@mail.med.upenn.edu,

    Harry Ischiropoulos

Authors
  1. Daniel J Rader
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  2. Harry Ischiropoulos
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Rader, D., Ischiropoulos, H. 'Multipurpose oxidase' in atherogenesis. Nat Med 13, 1146–1147 (2007). https://doi.org/10.1038/nm1007-1146b

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  • DOI: https://doi.org/10.1038/nm1007-1146b

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