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Where lies the blame for resistance—tumor or host?

Cytokine signaling from the tumor microenvironment can allow leukemia cells to survive targeted imatinib therapy, in the first report of a non-autonomous resistance mechanism.

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Figure 1: Mechanisms of resistance to targeted cancer therapy.


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Sawyers, C. Where lies the blame for resistance—tumor or host?. Nat Med 13, 1144–1145 (2007).

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