Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Keeping quiet: microRNAs in HIV-1 latency

MicroRNAs contribute to HIV-1 latency in resting T cells. This finding could potentially be used in the development of therapies targeted to purge the latent reservoir in an effort to clear the body of virus (pages 1241–1247).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: MicroRNAs (miRNAs) contribute to HIV-1 latency.

Kim Caesar


  1. Palella, F.J. et al. N. Engl. J. Med. 338, 853–860 (1998).

    Article  Google Scholar 

  2. Han, Y., Wind-Rotolo, M., Yang, H.C., Siliciano, J.D. & Siliciano, R.F. Nat. Rev. Microbiol. 5, 95–106 (2007).

    Article  CAS  Google Scholar 

  3. Siliciano, J.D. et al. Nat. Med. 9, 727–728 (2003).

    Article  CAS  Google Scholar 

  4. Lassen, K., Han, Y., Zhou, Y., Siliciano, J. & Siliciano, R.F. Trends Mol. Med. 10, 525–531 (2004).

    Article  CAS  Google Scholar 

  5. Peterson, S., Reid, A.P., Kim, S. & Siliciano, R.F. Advances in Pharmacology HIV-1: Molecular Biology and Pathogenesis Viral Mechanisms 2nd edn., 411–425 (Academic Press, 2007).

    Google Scholar 

  6. Huang, J.-L. et al. Nat. Med. 13, 1241–1247 (2007).

    Article  CAS  Google Scholar 

  7. Du, T. & Zamore, P.D. Cell Res. 17, 661–663 (2007).

    Article  CAS  Google Scholar 

  8. Cullen, B.R. Nat. Immunol. 7, 563–567 (2006).

    Article  CAS  Google Scholar 

  9. Lecellier, C.H. et al. Science 308, 557–560 (2005).

    Article  CAS  Google Scholar 

  10. Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M. & Sarnow, P. Science 309, 1577–1581 (2005).

    Article  CAS  Google Scholar 

  11. Triboulet, R. et al. Science 315, 1579–1582 (2007).

    Article  CAS  Google Scholar 

  12. Lewis, B.P., Burge, C.B. & Bartel, D.P. Cell 120, 15–20 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Han, Y., Siliciano, R. Keeping quiet: microRNAs in HIV-1 latency. Nat Med 13, 1138–1140 (2007).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing