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It's what you do with the fat that matters!

Obesity and a diet rich in saturated fatty acids can lead to high lipid levels in the liver and insulin resistance. However, inhibition of a key enzyme that elongates long-chain saturated fatty acids can protect against insulin resistance in fatty livers, even with concurrent obesity (pages 1193–1202).

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Figure 1: Loss of Elovl6 leads to improved insulin signaling even in fatty livers.

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Bruce, C., Febbraio, M. It's what you do with the fat that matters!. Nat Med 13, 1137–1138 (2007). https://doi.org/10.1038/nm1007-1137

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