HIV causes a chronic infection that overwhelms the immune system and leads to T-cell exhaustion. Three groups now report that a signaling molecule that dampens immune responses may tucker out the T cells (1198–1202).
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Farrell, A. Defeating T-cell fatigue in HIV. Nat Med 12, 1124–1125 (2006). https://doi.org/10.1038/nm1006-1124