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Fast track to the porphyrias

In susceptible individuals, fasting can trigger an attack of acute porphyria—a syndrome caused by the neurotoxic effects of precursors to porphyrins. The mechanistic basis for this trigger is now uncovered.

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Figure 1: Regulation of heme biosynthesis in the liver.

Katie Ris

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Phillips, J., Kushner, J. Fast track to the porphyrias. Nat Med 11, 1049–1050 (2005). https://doi.org/10.1038/nm1005-1049

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