Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Old approach yields new antibiotic

Antibiotic discovery has been stalled for well over a decade. The discovery of a new antibiotic with an unexpected mechanism of action could reinvigorate this lagging field (pages 1082–1087).

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bacterial protein degradation by the ClpXP protease.

Katie Ris

References

  1. Projan, S.J. & Shlase, D.M. Clin. Microbiol. Infect. 10, 18–22 (2004).

    Article  Google Scholar 

  2. Projan, S.J. Curr. Opin. Microbiol. 6, 427–430 (2003).

    Article  Google Scholar 

  3. Brötz-Oesterhelt, H. et al. Nat. Med. 11, 1082–1087 (2005).

    Article  Google Scholar 

  4. Wang, J. Hartling, J.A. & Flanagan, J.M. Cell 91, 447–456 (1997).

    Article  CAS  Google Scholar 

  5. Kim, Y. et al. Nat. Struct. Biol. 8, 230–233 (2001).

    Article  CAS  Google Scholar 

  6. Gottesman, S., Roche., E. Zhou, Y.N., Sauer, R.T. Genes Dev. 12, 1338–1347 (1998).

    Article  CAS  Google Scholar 

  7. Ades, S.E. Curr. Biol. 14, R924–926 (2004).

    Article  CAS  Google Scholar 

  8. Projan, S.J. Curr. Opin. Pharmacol. 2, 513–522 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blanchard, J. Old approach yields new antibiotic. Nat Med 11, 1045–1046 (2005). https://doi.org/10.1038/nm1005-1045

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1005-1045

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing