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Perspectives on the properties of stem cells

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  1. 1

    Stem cell. Wikipedia. (Accessed 20 August 2005).

  2. 2

    Siminovitch, L., McCulloch, E.A. & Till, J.E. J. Cell. Comp. Physiol. 62, 327–336 (1963).

    CAS  Article  Google Scholar 

  3. 3

    McCulloch, E.A. in: Stem Cells Handbook. (ed. Sell, S.) 119–131 (Humana Press, Totowa, New Jersey, 2003).

    Book  Google Scholar 

  4. 4

    Till, J.E. & McCulloch, E.A. Radiat. Res. 14, 213–222 (1961).

    CAS  Article  Google Scholar 

  5. 5

    McCulloch, E.A. & Till, J.E. Radiat. Res. 13, 115–125 (1960).

    CAS  Article  Google Scholar 

  6. 6

    McCulloch, E.A. The Ontario Cancer Institute: Successes and Reverses at Sherbourne Street. 46–60 (McGill-Queen's University Press, Montreal & Kingston, 2003).

    Google Scholar 

  7. 7

    Becker, A.J., McCulloch, E.A. & Till, J.E. Nature 197, 452–454 (1963).

    CAS  Article  Google Scholar 

  8. 8

    Siminovitch, L., Till, J.E. & McCulloch, E.A. J. Cell. Comp. Physiol. 64, 23–32 (1964).

    CAS  Article  Google Scholar 

  9. 9

    Till, J.E., McCulloch, E.A. & Siminovitch, L. Proc. Natl. Acad. Sci. USA 51, 29–36 (1964).

    CAS  Article  Google Scholar 

  10. 10

    Vogel, H., Niewisch, H. & Matioli, G. J. Theor. Biol. 22, 249–270 (1969).

    CAS  Article  Google Scholar 

  11. 11

    Benveniste, P., Cantin, C., Hyam, D. & Iscove, N.N. Nat. Immunol. 4, 708–713 (2003).

    CAS  Article  Google Scholar 

  12. 12

    Shizuru, J.A., Negrin, R.S. & Weissman, I.L. Ann. Rev. Med. 56, 509–538 (2005).

    CAS  Article  Google Scholar 

  13. 13

    Wulf, G.G., Jackson, K.A. & Goodell, M.A. Exp. Hematol. 29, 1361–1370 (2001).

    CAS  Article  Google Scholar 

  14. 14

    Jackson, K.A., Majka, S.M., Wulf, G.G. & Goodell, M.A. J. Cell. Biochem. Suppl. 38, 1–6 (2002).

    Article  Google Scholar 

  15. 15

    Massengale, M., Wagers, A.J., Vogel, H. & Weissman, I.L. J. Exp. Med. 201, 1579–1589 (2005).

    CAS  Article  Google Scholar 

  16. 16

    Greco, F.A. & Hainsworth, J.D. CA Cancer J. Clin. 42, 96–115 (1992).

    CAS  Article  Google Scholar 

  17. 17

    McCulloch, E.A. Leukemia 17, 1042–1048 (2003).

    CAS  Article  Google Scholar 

  18. 18

    Parson, A.B. The Proteus Effect: Stem Cells and Their Promise for Medicine. (Joseph Henry, Washington, 2004).

    Google Scholar 

  19. 19

    Finkel, E. Stem Cells: Controversy at the Frontiers of Science. 17–46 (ABC Books, Australian Broadcasting Corporation, Sydney, 2005).

    Google Scholar 

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We thank the many talented colleagues who participated in our research programs, our families and mentors for their encouragement, and the research agencies that supported our efforts.

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McCulloch, E., Till, J. Perspectives on the properties of stem cells. Nat Med 11, 1026–1028 (2005).

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