After primary Leishmania major infection, two populations of CD4+ T cells, termed 'effector' and 'central memory' T cells, are generated. Work in mice shows that both populations can mediate protection against subsequent infection, and that persistent infection keeps the effector response robust (pages 1104–1110).
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Seder, R., Sacks, D. Memory may not need reminding. Nat Med 10, 1045–1047 (2004). https://doi.org/10.1038/nm1004-1045
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DOI: https://doi.org/10.1038/nm1004-1045
