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HIV's great escape

Nature Medicine volume 9, pages 1262–1263 (2003)Cite this article

Viruses need cellular proteins to help them escape from cells. New results show that HIV and other viruses use the cellular machinery that normally delivers proteins to late endosomes and lysosomes.

The plasma membrane and the membranes that form the organelles of the exocytic and endocytic pathways can vesiculate in two directions. Inward vesiculation generates vesicles that bud into the cytoplasm. Outward vesiculation generates vesicles that bud out from the plasma membrane or into the lumina of organelles.

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Figure 1: HIV assembly occurs either at the plasma membrane or on late endosomes.

Kimberly Homer

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Authors and Affiliations

  1. MRC Laboratory for Molecular Cell Biology and Dept of Biochemistry, University College London, Gower Street, London, WC1E 6BT, UK

    Mark Marsh & Markus Thali

  2. Department of Microbiology and Molecular Genetics, University of Vermont, 318 Stafford Hall, 95 Carrigan Drive, Burlington, 05405-0084, Vermont, USA

    Mark Marsh & Markus Thali

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Marsh, M., Thali, M. HIV's great escape. Nat Med 9, 1262–1263 (2003). https://doi.org/10.1038/nm1003-1262

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