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Inflammation intersection: gp130 balances gut irritation and stomach cancer

The stomach and the intestine respond differently to inflammation. Work on the cytokine receptor gp130 helps explain why cancer develops in the stomach and inflammatory bowel disease hits the intestine (pages 1089–1097).

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Figure 1: Model for SHP2/Erk, STAT signaling and trefoil (TFF) gene expression in gastric neoplasia and inflammatory bowel disease.

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Wang, T., Goldenring, J. Inflammation intersection: gp130 balances gut irritation and stomach cancer. Nat Med 8, 1080–1082 (2002). https://doi.org/10.1038/nm1002-1080

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