The cell-cycle inhibitor p27 is phosphorylated by the Akt kinase in breast cancer, according to three new studies. This phosphorylation keeps p27 in the cytoplasm and correlates with cancer aggressiveness (pages 1136–1144, 1145–1152 and 1153–1160.)
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Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells
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