Breast cancer banishes p27 from nucleus

The cell-cycle inhibitor p27 is phosphorylated by the Akt kinase in breast cancer, according to three new studies. This phosphorylation keeps p27 in the cytoplasm and correlates with cancer aggressiveness (pages 1136–1144, 1145–1152 and 1153–1160.)

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Figure 1: p27 as a tumor-suppressor protein.

Kimberly Homer


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