Estrogen derivatives have been found to inhibit superoxide dismutase and selectively kill human leukemia cells in vitro. But is SOD a realistic target for human cancer therapy?
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References
Halliwell, B. & Gutteridge, J.M.C. in Free Radicals in Biology and Medicine, 3rd edition. (Oxford University Press, UK, 1999).
Hampton, M.B., Fadeel, B., Orrenius, S. Redox regulation of the caspases during apoptosis. Ann. NY Acad. Sci. 854, 328–335 (1998).
Jacobson, M.D. & Raff, M.C. Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374, 814–816 (1995).
Huang, P., Feng, L., Oldham, E.A., Keating, M.J. & Plunkett, W. Superoxide dismutase: a novel target for selective killing of cancer cells. Nature (in the press).
Huang, T.T., Carlson, E.J., Raineri, I., Gillespie, A.M., Kozy, H., Epstein, C.J. The use of transgenic and mutant mice to study oxygen free radical metabolism. Ann. NY Acad. Sci. 893, 95–112 (1999).
Beyer, W.F. Jr. & Fridovich, I. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. Anal. Biochem. 161, 559–566 (1987).
Zhong, W., Oberley, L.W., Oberley, T.D. & St Clair, D.K. Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene 14, 481–490 (1997).
Malafa, M., Margenthaler, J., Webb, B., Neitzel, L. & Christophersen, M. MnSOD expression is increased in metastatic gastric cancer. J. Surg. Res. 88, 130–134 (2000).
Westman, N.G. & Marklund, S.L. Copper- and zinc-containing superoxide dismutase and manganese-containing superoxide dismutase in human tissues and human malignant tumors. Cancer Res. 41, 2962–2966 (1981).
Clement, M.V. & Pervaiz, S. Reactive oxygen intermediates regulate cellular apoptosis response to apoptotic stimuli: an hypothesis. Free Rad. Res. 30, 247–252 (1999).
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Halliwell, B. A super way to kill cancer cells?. Nat Med 6, 1105–1106 (2000). https://doi.org/10.1038/80436
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DOI: https://doi.org/10.1038/80436
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TRAIL-based gene delivery and therapeutic strategies
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