The ubiquitin system

Nature Medicine volume 6, pages1073–1081(2000)Cite this article

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Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system.
Figure 2: The ubiquitin pathway, then and now.
Figure 3: Accelerated or decreased rates of ubiquitin-mediated proteolysis can underlie the pathogenesis of human diseases.
Figure 4: Drug targeting of an E3 enzyme can become a ‘double-edged sword’.
Figure 5: The ubiquitin system of S. cerevisiae51.
Figure 6: The N-end rule pathway.
Figure 7: Ubiquitin-dependent activation of peptide import in S. cerevisiae20.

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Affiliations

  1. Unit of Biochemistry, Technion-Israel Institute of Technology, Faculty of Medicine, P.O. Box 9649, Haifa, 31096, Israel

    • Avram Hershko
    •  & Aaron Ciechanover

  2. Smits Professor of Cell Biology, Division of Biology, California Institute of Technology, 1200 East California Blvd., Pasadena, 91125, CA

    • Alexander Varshavsky

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Hershko, A., Ciechanover, A. & Varshavsky, A. The ubiquitin system. Nat Med 6, 1073–1081 (2000) doi:10.1038/80384

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