Somatic cell nuclear 'reprogramming' in livestock species is now routine in many laboratories. Here, Robert Lanza, Jose Cibelli and Michael West discuss how these techniques may soon be used to clone genetically matched cells and tissues for transplantation into patients suffering from a wide range of disorders that result from tissue loss or dysfunction.
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Thomson, J.A. et al. Embryonic stem cell lines derived from human blastocytes. Science 282,1145–1147 (1998).
Shamblott, M.J. et al. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc. Natl. Acad. Sci. USA 95, 13726–13731 (1998).
Cibelli, J.B. et al. Transgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells. Nature Biotechnol. 16, 642–646 (1998).
Langer, R. & Vacanti, J.P. Tissue engineering. Science 260, 920–926 (1993).
Lanza, R.P. Langer, R. & Chick, W.L. Principles of Tissue Engineering (Academic, San Diego, California, 1997).
Mooney, D.J. & Mikos, A.G. Growing new organs. Sci. Am. 280, 60–65 (1999).
Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J. & Campbell, K.H.S. Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810–813 (1997).
Campbell, K.H.S., McWhir, J., Ritchie, W.A. & Wilmut, I. Sheep cloned by nuclear transfer from cultured cell line. Nature 380, 64–66 (1996).
Kato, Y. et al. Eight calves cloned from somatic cells of a single adult. Science 262, 2095–2098 (1998).
Cibelli, J.B. et al. Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science 280, 1256–1258 (1998).
Baguisi, A. et al. Production of goats by somatic cell nuclear transfer. Nature Biotechnol. 17, 456–461 (1999).
Robl, J., Cibelli, J. & Stice, S.L. Embryonic or stem-like cell lines produced by cross species nuclear transplantation. International Patent Application Number WO 98/07841. World Intellectual Property Organization, 26 February 1998.
Kenyon, L. & Moraes, C.T. Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids. Proc. Natl. Acad. Sci. USA 94, 9131–9135 (1997).
Dominko, T. et al. Bovine oocyte cytoplasm supports development of embryos produced by nuclear transfer of somatic cell nuclei from various mammalian species. Biol. Reprod. 60, 1496–1502 (1999).
Vogel, G. Harnessing the power of stem cells. Science 283, 1432–1434 (1999).
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Lanza, R., Cibelli, J. & West, M. Human therapeutic cloning. Nat Med 5, 975–977 (1999). https://doi.org/10.1038/12404
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