Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Translational research comes of age

p53 gene therapy brings clinical benefits to lung cancer patients (pages 985-991).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Harris, C.C. p53 Tumor suppressor gene: From the basic research laboratory to the clinic — an abridged historical perspective. Carcinogenesis 17, 1187–1198 (1996).

    Article  CAS  Google Scholar 

  2. Roth, J.A. et al. Retroviral-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med. 2, 985–991 (1996).

    Article  CAS  Google Scholar 

  3. Cai, D.W., Mukhopadhyay, T., Liu, Y., Fujiwara, T. & Roth, J.A. Stable expression of the wild-type p53 gene in human lung cancer cells after retro-virus-mediated gene transfer. Hum. Gene Ther. 4, 617–624 (1993).

    Article  CAS  Google Scholar 

  4. Takahashi, T. et al. Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions. Cancer Res 52, 2340–2343 (1992).

    CAS  PubMed  Google Scholar 

  5. Takahashi, T. et al p53: A frequent target for genetic abnormalities in lung cancer. Science 246, 491–494 (1989).

    Article  CAS  Google Scholar 

  6. Fujiwara, T. et al. Therapeutic effect of a retro viral wild-type p53 expression vector in an ortho-topic lung cancer model. j. Natl. Cancer Inst. 86, 1458–1462 (1994).

    Article  CAS  Google Scholar 

  7. Jacks, T. & Weinberg, R.A. Cell-cycle control and its watchman. Naure 381, 643–644 (1996).

    CAS  Google Scholar 

  8. Sozzi, G. et al. Deletions of 17p and p53 mutations in preneoplastic lesions of the lung. Cancer Res. 52, 6079–6082 (1992).

    CAS  PubMed  Google Scholar 

  9. Sundaresan, V. et al. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 7, 1989–1997 (1992).

    CAS  Google Scholar 

  10. Hayashi, N., Sugimoto, Y., Tsuchiya, E., Ogawa, M. & Nakamura, Y. Somatic mutations of the MTS (Multiple tumor suppressor) 1/CDK4I (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas. Biochem. Biophys. Res. Commun. 202, 1426–1430 (1994).

    Article  CAS  Google Scholar 

  11. Gerwin, B.I. et al. Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1. Proc. Natl. Acad. Sci. USA 89, 2759–2763 (1992).

    Article  CAS  Google Scholar 

  12. Winter, S.F. et al. Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation. Cancer Res. 52, 4168–4174(1992).

    CAS  Google Scholar 

  13. Fujiwara, T. et al. A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res. 53, 4129–4133 (1993).

    CAS  PubMed  Google Scholar 

  14. Takeshima, Y. et al. p53 mutations in lung cancers from non-smoking atomic-bomb survivors. Lancet 342, 1520–1521 (1993).

    Article  CAS  Google Scholar 

  15. Mao, L., Hruban, R.H., Boyle, J.O., Tockman, M. & Sidransky, D. Detection of oncogene mutations in sputum precedes diagnosis of lung cancer. Cancer Res. 54, 1634–1637 (1994).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Minna, J., Gazdar, A. Translational research comes of age. Nat Med 2, 974–975 (1996). https://doi.org/10.1038/nm0996-974

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0996-974

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing