Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

No NO prevents parkinsonism

Inhibition of nitric oxide synthesis by 7-nitroindazole prevents destruction of dopamine neurons and parkinsonian symptoms in baboons treated with MPTP (page 1017–1021).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Jaffrey, S.R., Snyder, S.H., Nitric oxide A neural messenger Annu Rev Cell Dev Biol 11, 417–440 1995.

    Article  CAS  Google Scholar 

  2. Hantraye, P., et al. Inhibition of neuronal nitricoxide synthase prevents MPTP-induced parkinsonism in baboons. Nature Med. 2, 1017–1021 1996.

    Article  CAS  Google Scholar 

  3. Dawson, V.L., Kizushi, V.M., Huang, P.L., Snyder, S.H. & Dawson, T.M. Resistance to neurotoxicityin cortical cultures from neuronal nitric oxide syn-thase-deficient mice. j. Neurosci. 16, 2479–2487 1996.

    Article  CAS  Google Scholar 

  4. Huang, Z., et al. Effects of cerebral ischemia inmice deficient in neuronal nitric oxide synthase. Science 265, 1883–1885 1994.

    Article  CAS  Google Scholar 

  5. Lipton, S.A., et al. A redox-based mechanism forthe neuroprotective and neurodestructive effectsof nitric oxide and related nitroso-compounds. Nature 364, 626–632 1993.

    Article  CAS  Google Scholar 

  6. Zhang, J., Dawson, V.L., Dawson, T.M. & v Snyder, S.H. Nitric oxide activation of poly(ADP-ribose)synthetase in neurotoxicity. Science 263, 687–789 1994.

    Article  CAS  Google Scholar 

  7. Langston, J.W., Ballard, P., Tetrud, J.W. & Irwin, I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979–980 1983.

    Article  CAS  Google Scholar 

  8. Javitch, J.A., D'Amato, R.J., Strittmatter, S.M., Snyder, S.H. Parkinsonism-inducing neurotoxin,iV-methyl-4-pheny 1-1,2,3,6-tetrahydropy ridine:Uptake of the metaboliteN-methyl-4-phenylpyri-dine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA 82, 2173–2177 1985.

    Article  CAS  Google Scholar 

  9. Tipton, K.F., Singer, T.P. Advances in our understanding of the mechanisms of the neurotoxicityof MPTP and related compounds. j. Neurochem. 61, 1191–1206 1993

    Article  CAS  Google Scholar 

  10. Schulz, J.B., Matthews, R.T., Muqit, M.M.K., Browne, S.E., Beal, M.F. Inhibition of neuronalnitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. j.Neurochem. 64, 936–939 1995

    Article  CAS  Google Scholar 

  11. Przedborski, S. et al. Role of nitric oxide in MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced dopaminergic neurotoxicity. Proc. Natl.Acad. Sci. USA 93, 4565–4571 1996.

    Article  CAS  Google Scholar 

  12. Babbedge, R.C. . et al. Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br. J. Pharmacol. 110, 225–228 1993.

    Article  CAS  Google Scholar 

  13. Innis, R.B. et al. Single photon emission computed tomographic imaging demonstrates loss ofstriatal dopaminetransporters in Parkinson's discase. Proc. Natl. Acad. Sci. USA 90, 11965–11969 1993.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Snyder, S. No NO prevents parkinsonism. Nat Med 2, 965–966 (1996). https://doi.org/10.1038/nm0996-965

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0996-965

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing