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Turning a new phage

The idea of using bacteria-fighting viruses as a weapon against hard-to-treat infections is making a surprising comeback, but with a twist on how it has been attempted for nearly a century. Researchers and companies are now tweaking and deconstructing these bacteria killers in an effort to develop a new arsenal against antibiotic-resistant superbugs—one with more potency and a better likelihood of regulatory approval. Lauren Gravitz reports.

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References

  1. 1

    Wright, A., Hawkins, C.H., Änggård, E.E. & Harper, D.R. Clin. Otolaryngol. 34, 349–357 (2009).

    CAS  Article  Google Scholar 

  2. 2

    Lu, T.K. & Collins, J.J. Proc. Natl. Acad. Sci. USA 106, 4629–4634 (2009).

    CAS  Article  Google Scholar 

  3. 3

    Edgar, R., Friedman, N., Molshanski-Mor, S. & Qimron, U. Appl. Environ. Microbiol. 78, 744–751 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Fischetti, V.A., Gotschlich, E.C. & Bernheimer, A.W. J. Exp. Med. 133, 1105–1117 (1971).

    CAS  Article  Google Scholar 

  5. 5

    Nelson, D., Loomis, L. & Fischetti, V.A. Proc. Natl. Acad. Sci. USA 98, 4107–4112 (2001).

    CAS  Article  Google Scholar 

  6. 6

    Yoong, P., Schuch, R. Nelson, D. & Fischetti, V.A. J. Bacteriol. 186, 4808–4812 (2004).

    CAS  Article  Google Scholar 

  7. 7

    Pastagia, M. et al. Antimicrob. Agents Chemother. 55, 738–744 (2011).

    CAS  Article  Google Scholar 

  8. 8

    Schuch, R., Nelson, D. & Fischetti, V.A. Nature 418, 884–889 (2002).

    CAS  Article  Google Scholar 

  9. 9

    Vipra, A.A. et al. BMC Microbiol. 12, 41 (2012).

    CAS  Article  Google Scholar 

Download references

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Gravitz, L. Turning a new phage. Nat Med 18, 1318–1320 (2012). https://doi.org/10.1038/nm0912-1318

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