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  • Between Bedside and Bench
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Finding the tumor copycat: Approximating a human cancer

Nature Medicine volume 16, pages 976–977 (2010)Cite this article

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Years of developing cancer therapies targeted to specific molecular drivers have yielded some crucial advances, yet only 5% of such therapies tested in the clinic prove efficacious, indicating a need for marked improvement in predictive preclinical research1. Given that cancers are complex diseases with diverse molecular etiologies, the most predictive preclinical models require accurate engineering for the induction of cancer in situ.

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Figure 1: A de novo tumor model mimics the growth patterns of the human tumor and allows testing of alternative antitumor therapies to use in clinical trials.

Katie Ris

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Authors and Affiliations

  1. Terry Van Dyke is Head of the Mouse Cancer Genetics Program and Director of the Center for Advanced Preclinical Research at the National Cancer Institute, Frederick, Maryland, USA.,

    Terry Van Dyke

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  1. Terry Van Dyke
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Correspondence to Terry Van Dyke.

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The author declares no competing financial interests.

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Van Dyke, T. Finding the tumor copycat: Approximating a human cancer. Nat Med 16, 976–977 (2010). https://doi.org/10.1038/nm0910-976

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