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Cocaine sobers up

Nature Medicine volume 16, pages 969–970 (2010)Cite this article

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A drug that discourages alcohol ingestion has shown promise as a treatment for cocaine addiction. New findings in rats suggest a potential mechanism—the drug decreases amounts of dopamine in the brain (pages 1024–1028). Blocking enzymes that regulate dopamine abundance may be a new way to treat cocaine addiction and prevent relapse in humans.

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Figure 1: The metabolic and biosynthetic pathways underlying disulfiram treatment of cocaine addiction.

Katie Vicari

References

  1. Fuller, R.K. et al. J. Am. Med. Assoc. 256, 1449–1455 (1986).

    Article  CAS  Google Scholar 

  2. Carroll, K.M. et al. Arch. Gen. Psychiatry 61, 264–272 (2004).

    Article  CAS  Google Scholar 

  3. Arolfo, M.P. et al. Alcohol. Clin. Exp. Res. 33, 1935–1944 (2009).

    Article  Google Scholar 

  4. Yao, L. et al. Nat. Med. 16, 1024–1028 (2010).

    Article  CAS  Google Scholar 

  5. Bourdélat-Parks, B.N. et al. Psychopharmacology (Berl.) 183, 72–80 (2005).

    Article  Google Scholar 

  6. Schroeder, J.P. et al. Neuropsychopharmacology (in the press) 1038/npp.2010.127.

  7. Weinshenker, D. & Schroeder, J.P. Neuropsychopharmacology 32, 1433–1451 (2007).

    Article  CAS  Google Scholar 

  8. Gaval-Cruz, M. & Weinshenker, D. Mol. Interv. 9, 175–187 (2009).

    Article  CAS  Google Scholar 

  9. Zhang, X.Y. & Kosten, T.A. Biol. Psychiatry 57, 1202–1204 (2005).

    Article  CAS  Google Scholar 

  10. Leri, F., Flores, J., Rodaros, D. & Stewart, J. J. Neurosci. 22, 5713–5718 (2002).

    Article  CAS  Google Scholar 

  11. Stanley, W.C. et al. Br. J. Pharmacol. 121, 1803–1809 (1997).

    Article  CAS  Google Scholar 

  12. Burke, W.J. et al. Neurotoxicology 25, 101–115 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. David Weinshenker is in the Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.,

    David Weinshenker

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  1. David Weinshenker
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Correspondence to David Weinshenker.

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Competing interests

D.W. is co-inventor on a patent concerning the use of selective dopamine β-hydroxylase inhibitors for the treatment of cocaine dependence (US-2010-0105748-A1; “Methods and Compositions for Treatment of Drug Addiction”). He has also received research funds from Cephalon Pharmaceuticals for a separate project.

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Weinshenker, D. Cocaine sobers up. Nat Med 16, 969–970 (2010). https://doi.org/10.1038/nm0910-969

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