Thyroid hormones increase the energy metabolism of the body in a process called 'thyroid thermogenesis'. Its molecular mechanism, however, has been elusive. Recent findings in rats suggest that it is localized to brown adipose tissue—our one truly thermogenic organ—and is mediated via the brain (pages 1001–1008).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance
Nature Communications Open Access 25 November 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Silva, J.E. Physiol. Rev. 86, 435–464 (2006).
Lopez, M. et al. Nat. Med. 16, 1001–1008 (2010).
Fliers, E. et al. Trends Endocrinol. Metab. 21, 230–236 (2010).
Szekely, M. Acta Physiol. Hung. 37, 51–56 (1970).
Cannon, B. et al. Ann. N.Y. Acad. Sci. 856, 171–187 (1998).
King, B.M. Physiol. Behav. 87, 221–244 (2006).
Cannon, B. & Nedergaard, J. Physiol. Rev. 84, 277–359 (2004).
Enerbäck, S. et al. Nature 387, 90–94 (1997).
Cannon, B. & Nedergaard, J. Int. J. Obes. (in the press).
Nedergaard, J. et al. Am. J. Physiol. 293, E444–E452 (2007).
Saito, M. et al. Diabetes 58, 1526–1531 (2009).
Zingaretti, M.C. et al. FASEB J. 23, 3113–3120 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Cannon, B., Nedergaard, J. Thyroid hormones: igniting brown fat via the brain. Nat Med 16, 965–967 (2010). https://doi.org/10.1038/nm0910-965
Issue Date:
DOI: https://doi.org/10.1038/nm0910-965
This article is cited by
-
Selection-driven adaptation to the extreme Antarctic environment in the Emperor penguin
Heredity (2022)
-
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance
Nature Communications (2021)
-
A review of the peripheral levels of regulation by thyroid hormone
Journal of Comparative Physiology B (2016)