A safer stem cell: on guard against cancer

Before stem cell therapies become mainstream, several hurdles must be overcome. One challenge is developing air-tight approaches to assure that stem cell transplantation does not give rise to tumors. Another is finding safe ways to induce pluripotency in adult stem cells, which can then be used for transplantation. In Bedside to Bench, Evan Snyder and Rahul Jandial discuss the risks of tumorigenesis in stem cell therapies, and, in Bench to Bedside, Laura Clarke and Derek van der Kooy examine new ways to induce pluripotency.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Human NSCs, maintained in culture and starting to differentiate into neurons.

References

  1. 1

    Amariglio, N. et al. PLoS Med. 6, e1000029 (2009).

    Article  Google Scholar 

  2. 2

    Flax, J.D. et al. Nat. Biotechnol. 16, 1033–1039 (1998).

    CAS  Article  Google Scholar 

  3. 3

    Roy, N.S. et al. Nat. Med. 12, 1259–1268 (2006).

    CAS  Article  Google Scholar 

  4. 4

    Stemcells, Inc. <http://www.stemcellsinc.com/news/090608.html> (2008).

  5. 5

    Lee, J.P. et al. Nat. Med. 13, 439–447 (2007).

    CAS  Article  Google Scholar 

  6. 6

    Redmond, D.E. Jr. et al. Proc. Natl. Acad. Sci. USA 104, 12175–12180 (2007).

    CAS  Article  Google Scholar 

  7. 7

    Aboody, K.S. et al. Proc. Natl. Acad. Sci. USA 97, 12846–12851 (2000).

    CAS  Article  Google Scholar 

  8. 8

    Singh, S.K. et al. Cancer Res. 63, 5821–5828 (2003).

    CAS  PubMed  Google Scholar 

  9. 9

    Lapidot, T. et al. Nature 367, 645–648 (1994).

    CAS  Article  Google Scholar 

  10. 10

    Keller, C. & Capecchi, M.R. Cancer Res. 65, 7530–7532 (2005).

    CAS  Article  Google Scholar 

  11. 11

    Read, T.A. et al. Cancer Cell 15, 135–147 (2009).

    CAS  Article  Google Scholar 

  12. 12

    Yang, Z.J. et al. Cancer Cell 14, 135–145 (2008).

    CAS  Article  Google Scholar 

  13. 13

    Alcantara, L.S. et al. Cancer Cell 15, 45–56 (2009).

    Article  Google Scholar 

  14. 14

    Marumoto, T. et al. Nat. Med. 15, 110–116 (2009).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Evan Y Snyder.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Jandial, R., Snyder, E. A safer stem cell: on guard against cancer. Nat Med 15, 999–1001 (2009). https://doi.org/10.1038/nm0909-999

Download citation

Further reading