The advancement of translational medicine—from regional challenges to global solutions

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Figure 1: Diagrammatic view of a Translational Medicine Research Interface (TMRI).

References

  1. 1

    Goldsmith, Z.G. & Dhanasekaran, N. Int. J. Mol. Med. 13, 483–495 (2004).

    CAS  PubMed  Google Scholar 

  2. 2

    Waldman, S.A., Terzic, M.R. & Terzic, A. Clin. Pharmacol. Ther. 82, 343–347 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Hayday, A.C. & Peakman, M. Nat. Immunol. 9, 575–580 (2008).

    CAS  Article  Google Scholar 

  4. 4

    Fitzgerald, G.A. Nat. Rev. Drug Discov. 4, 815–818 (2005).

    CAS  Article  Google Scholar 

  5. 5

    Lesko, L.J. & Woodcock, J. Nat. Rev. Drug Discov. 3, 763–769 (2004).

    CAS  Article  Google Scholar 

  6. 6

    Hörig, H., Marincola, E. & Marincola, F. Nat. Med. 11, 705–708 (2005).

    Article  Google Scholar 

  7. 7

    Dickson, M. & Gagnon, J.P. Nat. Rev. Drug Discov. 3, 417–429 (2004).

    CAS  Article  Google Scholar 

  8. 8

    Persidis, A. & De Rubertis, F. Nat. Biotechnol. 18, 570–571 (2000).

    CAS  Article  Google Scholar 

  9. 9

    Dow Jones VentureSource. Venture Insights, 4Q 2008. 15–64 (Ernst & Young, 2008).

  10. 10

    Battelle Memorial Institute. Technology, Talent and Capital: State Bioscience Initiatives 2008 http://www.bio.org/local/battelle2008/State_Bioscience_Initiatives_2008.pdf (2008).

  11. 11

    Mankoff, S.P., Brander, C., Ferrone, S. & Marincola, F. J. Transl. Med. 2, 14 (2004).

    Article  Google Scholar 

  12. 12

    van den Broek, T., Tesser, J. & Albani, S. Expert Opin. Biol. Ther. 8, 1773–1785 (2008).

    CAS  Article  Google Scholar 

  13. 13

    Pober, J.S., Neuhauser, C.S. & Pober, J.M. FASEB J. 15, 2303–2313 (2001).

    CAS  Article  Google Scholar 

  14. 14

    Horton, R. Lancet 364, 1995–1996 (2004).

    Article  Google Scholar 

  15. 15

    Shuchman, M. N. Engl. J. Med. 357, 1365–1368 (2007).

    CAS  Article  Google Scholar 

  16. 16

    Organization for Economic Co-operation and Development. OECD health data 2008: statistics and indicators for 30 countries. http://www.oecd.org/health/healthdata (2008).

  17. 17

    American College of Physicians. Ann. Intern. Med. 148, 55–75 (2008).

  18. 18

    Zerhouni, E.A. & Alving, B. Transl. Res. 148, 4–5 (2006).

    Article  Google Scholar 

  19. 19

    Barrett, J.S. AAPS J. 10, 9–14 (2008).

    Article  Google Scholar 

  20. 20

    Rothaermel, F.T. & Thursby, M. Res. Policy 34, 305–320 (2005).

    Article  Google Scholar 

  21. 21

    Moses, H., Dorsey, E.R., Matheson, D.H.M. & Thier, S.O. J. Am. Med. Assoc. 294, 1333–1342 (2005).

    CAS  Article  Google Scholar 

  22. 22

    Yetley, E.A. Novartis Found. Symp. 282, 59–68; discussion 69–76, 212–218 (2007).

    Article  Google Scholar 

  23. 23

    Woodcock, J. & Woosley, R. Annu. Rev. Med. 59, 1–12 (2008).

    CAS  Article  Google Scholar 

  24. 24

    Sepkowitz, K.A. N. Engl. J. Med. 344, 1764–1772 (2001).

    CAS  Article  Google Scholar 

  25. 25

    Schuler, G.D. et al. Science 274, 540–546 (1996).

    CAS  Article  Google Scholar 

  26. 26

    Jawaheer, D. et al. Arthritis Rheum. 48, 906–916 (2003).

    CAS  Article  Google Scholar 

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Acknowledgements

We thank J. Colomb for her contribution to developing the manuscript. We also thank E. Albani, J. Colomb, L. Guidotti, D. Hafler, J. Hafler, M. von Herrath, K. Joiner, E. Muter, M.-G. Roncarolo, N. Rosenblum, V. Seyfert-Margolis and T. Staeva, charter members of the Eureka Institute for Translational Medicine. The Eureka Institute is committed to preparing future leaders in translational medicine along the lines discussed in this article. We also thank M. Lotz and P. Coffer for critically reading the manuscript.

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Correspondence to Salvatore Albani.

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Albani, S., Prakken, B. The advancement of translational medicine—from regional challenges to global solutions. Nat Med 15, 1006–1009 (2009). https://doi.org/10.1038/nm0909-1006

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