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Counteracting clotting in sepsis

The complexity of factors that regulate bleeding and coagulation has long confounded researchers. Andrew Wei and Shaun Jackson help clear the air by examining clinical findings pointing to a mechanistic basis for a common bleeding disorder, immune thrombocytopenic purpura. Mark Kahn tackles two research studies that could lead to improved therapies for a coagulation syndrome that hits people with severe sepsis.

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Figure 1: Opposing cell-specific roles for PAR1 during sepsis.

Katie Vicari

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Kahn, M. Counteracting clotting in sepsis. Nat Med 14, 918–919 (2008). https://doi.org/10.1038/nm0908-918

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