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Mitochondrial missile defense

A relatively obscure immune cell, the eosinophil, has a dramatic way of defending against pathogens. It rapidly ejects mitochondrial DNA, ensnaring bacteria and hastening their demise (pages 949–953).

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Figure 1: Eosinophils differentiate under the stimulation of IL-5.

Katie Vicari


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Competing interests

M.E.R. is associated with the following companies that are pursuing drugs that target gastrointestinal eosinophils: Ception Therapeutics (consultant and stock owner), Novartis (consultant) and Merck (consultant).

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Nizet, V., Rothenberg, M. Mitochondrial missile defense. Nat Med 14, 910–912 (2008).

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