A relatively obscure immune cell, the eosinophil, has a dramatic way of defending against pathogens. It rapidly ejects mitochondrial DNA, ensnaring bacteria and hastening their demise (pages 949–953).
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M.E.R. is associated with the following companies that are pursuing drugs that target gastrointestinal eosinophils: Ception Therapeutics (consultant and stock owner), Novartis (consultant) and Merck (consultant).
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Nizet, V., Rothenberg, M. Mitochondrial missile defense. Nat Med 14, 910–912 (2008). https://doi.org/10.1038/nm0908-910
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DOI: https://doi.org/10.1038/nm0908-910
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