Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Mitochondrial missile defense

A relatively obscure immune cell, the eosinophil, has a dramatic way of defending against pathogens. It rapidly ejects mitochondrial DNA, ensnaring bacteria and hastening their demise (pages 949–953).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Eosinophils differentiate under the stimulation of IL-5.

Katie Vicari

References

  1. Rothenberg, M.E. . J. Allergy Clin. Immunol. 113, 11–28; quiz 29 (2004).

    Article  CAS  Google Scholar 

  2. Rothenberg, M.E. & Hogan, S.P. Annu. Rev. Immunol. 24, 147–174 (2006).

    Article  CAS  Google Scholar 

  3. Yousefi, S. et al. Nat. Med. 949–953 (2008).

  4. Jacobsen, E.A., Taranova, A.G., Lee, N.A. & Lee, J.J. J. Allergy Clin. Immunol. 119, 1313–1320 (2007).

    Article  CAS  Google Scholar 

  5. Yang, D. et al. J. Exp. Med. 205, 79–90 (2008).

    Article  CAS  Google Scholar 

  6. Jacobsen, E.A. et al. J. Exp. Med. 205, 699–710 (2008).

    Article  CAS  Google Scholar 

  7. Walsh, E.R. et al. J. Exp. Med. 205, 1285–1292 (2008).

    Article  CAS  Google Scholar 

  8. Mishra, A., Hogan, S.P., Lee, J.J., Foster, P.S. & Rothenberg, M.E. J. Clin. Invest. 103, 1719–1727 (1999).

    Article  CAS  Google Scholar 

  9. Brinkmann, V. et al. Science 303, 1532–1535 (2004).

    Article  CAS  Google Scholar 

  10. Buchanan, J.T. et al. Curr. Biol. 16, 396–400 (2006).

    Article  CAS  Google Scholar 

  11. Fuchs, T.A. et al. J. Cell Biol. 176, 231–241 (2007).

    Article  CAS  Google Scholar 

  12. Gray, M.W., Burger, G. & Lang, B.F. Science 283, 1476–1481 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

M.E.R. is associated with the following companies that are pursuing drugs that target gastrointestinal eosinophils: Ception Therapeutics (consultant and stock owner), Novartis (consultant) and Merck (consultant).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nizet, V., Rothenberg, M. Mitochondrial missile defense. Nat Med 14, 910–912 (2008). https://doi.org/10.1038/nm0908-910

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0908-910

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing