Upregulation of a protein involved in lysosomal degradation of proteins helps stave off some of the cellular decline observed with aging. The findings could lead to new approaches to fend off age-related disease or even extend lifespan (pages 959–965).
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References
Zhang, C. & Cuervo, A.M. Nat. Med. 14, 959–965 (2008).
Hara, T. et al. Nature 441, 885–889 (2006).
Komatsu, M. et al. J. Cell Biol. 169, 425–434 (2005).
Ravikumar, B. et al. Nat. Genet. 36, 585–595 (2004).
Eskelinen, E.L. et al. Mol. Biol. Cell 13, 3355–3368 (2002).
González-Polo, R.A. et al. J. Cell Sci. 118, 3091–3102 (2005).
Jäger, S. et al. J. Cell Sci. 117, 4837–4848 (2004).
Lichter-Konecki, U. et al. Differentiation 65, 43–58 (1999).
Tanaka, Y. et al. Nature 406, 902–906 (2000).
Bergamini, E., Cavallini, G., Donati, A. & Gori, Z. Ann. NY Acad. Sci. 1114, 69–78 (2007).
Melendez, A. et al. Science 301, 1387–1391 (2003).
Simonsen, A. et al. Autophagy 4, 176–184 (2008).
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Saftig, P., Eskelinen, EL. Live longer with LAMP-2. Nat Med 14, 909–910 (2008). https://doi.org/10.1038/nm0908-909
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DOI: https://doi.org/10.1038/nm0908-909
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