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A skeleton key to metabolism

The bone-specific protein osteocalcin has now been shown to act as a hormone that profoundly affects glucose and fat metabolism. This discovery completes an endocrine circuit with the skeleton as a ductless gland.

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Figure 1: Osteocalcin (Ocn) is produced by differentiated osteoblasts, where it is γ-carboxylated to the predominant circulating form (GlaOcn).

Katie Ris-Vicari

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Martin, T. A skeleton key to metabolism. Nat Med 13, 1021–1023 (2007). https://doi.org/10.1038/nm0907-1021

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